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Yet, preterm infants appear to be especially vulnerable to adverse effects of -tocopherol supplementation, and supplemental vitamin E should be administered only under controlled supervision by a pediatrician (122)

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Cells also export GSSG or form reversible mixed disulphides with protein thiols when redox conditions change

Mechanistically, the authors reported that the uremic toxin, indoxyl sulfate, activates the aryl hydrocarbon receptor (AhR), and experiments using AhR knockout mice confirmed that AhR activation is a key driver of BBB damage (Bobot et al., 2020)